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Related Experiment Videos

Analysis of prostatic fluid in prostatic disease.

J T Grayhack, E F Wendel, C Lee

    Cancer Treatment Reports
    |March 1, 1977
    PubMed
    Summary

    Prostate cancer diagnosis may be improved by analyzing expressed prostatic fluid. Studies show a shift in lactic dehydrogenase (LDH) isoenzymes and altered levels of acid phosphatase and protein in patients with malignancy.

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    Area of Science:

    • Biochemistry
    • Oncology
    • Urology

    Background:

    • Prostatic fluid analysis offers potential for diagnosing prostate cancer.
    • Previous pilot studies indicated specific biochemical changes in patients with prostatic malignancy.

    Purpose of the Study:

    • To confirm previous pilot observations regarding biochemical markers in expressed prostatic fluid.
    • To investigate the diagnostic utility of lactic dehydrogenase (LDH) isoenzymes, acid phosphatase, and protein concentrations in prostate cancer.

    Main Methods:

    • Analysis of expressed prostatic fluid from patients.
    • Quantification of lactic dehydrogenase (LDH) isoenzymes, acid phosphatase, and total protein concentrations.

    Main Results:

    • Confirmed a shift towards LDHV predominance in lactic dehydrogenase (LDH) isoenzymes in patients with prostatic malignancy.
    • Observed decreased acid phosphatase and increased protein concentrations in the presence of prostate cancer.

    Conclusions:

    • Findings suggest a diffuse metabolic alteration in the prostate associated with carcinoma.
    • These biochemical changes in prostatic fluid may serve as potential biomarkers for prostate cancer detection.

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