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Related Experiment Videos

Free and total lipid myo-inositol concentrations decrease with age in human brain.

C E Stokes, K R Gillon, J N Hawthorne

    Biochimica Et Biophysica Acta
    |August 29, 1983
    PubMed
    Summary

    Brain myo-inositol levels significantly decrease with age. This study tracked free and total inositol concentrations in human brain tissue, revealing a notable decline from young adulthood to old age.

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    Area of Science:

    • Neurochemistry
    • Aging Research
    • Metabolic Pathways

    Background:

    • Myo-inositol is actively transported into the brain, maintaining higher concentrations than in the blood.
    • Inositol plays crucial roles in cellular function and signaling within the central nervous system.

    Purpose of the Study:

    • To investigate age-related changes in myo-inositol concentrations in the human anterior temporal cortex.
    • To analyze both free and total lipid inositol levels across different age groups.

    Main Methods:

    • Analysis of human anterior temporal cortex samples from individuals of varying ages.
    • Quantification of free and total lipid inositol concentrations per gram of protein.

    Main Results:

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  • Inositol concentration was approximately 60 mumols/g protein at age 20.
  • A steady decline was observed, with concentrations halving by age 90.
  • Total inositol lipid concentration also showed a similar age-dependent decrease.

    • Conclusions:

    • Myo-inositol levels in the human brain decrease significantly with advancing age.
    • The findings suggest a potential age-related alteration in myo-inositol homeostasis or metabolism.
    • Further research is warranted to understand the functional implications of declining brain inositol with age.