[Protective effect of allopurinol during chemotherapy with 5-fluorouracil of mouse blast leukemia]

The possibility of raising the efficacy of the treatment with lethal doses of 5-fluorouracil (FU) under body protection by allopurinol has been demonstrated in experimental blast leukemia (hemoblastosis) La. The protective effect was found to be dependent on dose-time correlations between FU and allopurinol. Oral administration of allopurinol in high doses of 150-200 mg/kg 30 minutes before intraperitoneal injection of FU provoked the development of CNS toxic lesions and death of part of mice in the next 72 hours. The data obtained provide evidence in favour of trying the efficacy of combined allopurinol and FU for non-lymphoid leukemias of man.