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Surgery in recurrent malignant melanoma.

C P Karakousis, R Moore, E D Holyoke

    Cancer
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Surgical excision combined with chemotherapy improves outcomes for malignant melanoma patients with limited metastatic lesions and a long disease-free interval. This treatment offers better palliation for select patients with advanced or recurrent disease.

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    Long-term prognostic significance of HSP-70, c-myc and HLA-DR expression in patients with malignant melanoma.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2001

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Medical Oncology

    Background:

    • Malignant melanoma is a significant public health concern.
    • Recurrent and advanced stages often present treatment challenges.
    • Adjuvant therapy following surgical resection is a key management strategy.

    Purpose of the Study:

    • To evaluate the efficacy of surgical excision followed by adjuvant chemotherapy in patients with resectable, recurrent malignant melanoma.
    • To identify prognostic factors associated with disease-free survival in this patient cohort.

    Main Methods:

    • Seventy-nine consecutive patients with resectable, recurrent malignant melanoma underwent surgical excision.
    • Patients received adjuvant chemotherapy post-surgery.
    • Outcomes were assessed based on disease stage, number of metastatic lesions, and prior disease-free interval.

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    Main Results:

    • Stage IIIA: 6 of 7 patients alive, 5 disease-free at 27 months.
    • Stage IIIB: 10 of 33 patients (30%) disease-free at 30 months.
    • Stage IV: 7 of 27 patients (25%) disease-free at 36 months.
    • Favorable prognostic factors included ≤3 discrete metastatic lesions and a long prior disease-free interval.

    Conclusions:

    • Surgical removal of metastatic lesions combined with chemotherapy offers improved palliation for malignant melanoma.
    • Patients with a limited number of metastatic lesions and a long disease-free interval benefit most from this combined approach.
    • This strategy shows potential for improving outcomes in select patients with advanced or recurrent malignant melanoma.