Related Experiment Video
Updated: Aug 23, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Asthma due to Central American walnut (Juglans olanchana) dust
Abstract:
The purpose of our study was to describe a case of asthma due to Central American walnut (Juglans olanchana) dust and to ascertain whether an IgE antibody mechanism was implicated. The subject was a 48-year-old man who developed asthma following exposure to Central American walnut dust. Although intradermal testing with an aqueous extract of walnut dust produced no response, inhalation challenge with the extract produced significant bronchoconstriction. Another asthmatic person exposed to the wood dust had a positive skin test, but did not respond to the bronchial challenge. A direct radioallergosorbent test (RAST) on both subjects showed no evidence of serum IgE antibodies to Central American walnut dust. Consequently, the mechanism responsible for the sensitivity to the walnut dust remains unknown.
Related Concept Videos
Antiasthma Drugs: Methylxanthines
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma I: Introduction
Asthma III: Clinical Manifestations

