Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related morphine kinetics.

J A Owen, D S Sitar, L Berger

    Clinical Pharmacology and Therapeutics
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.

    Genes, brain, and behavior·2008
    Same author

    Use of antiviral prophylaxis in influenza outbreaks in long term care facilities.

    The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2007
    Same author

    British and Canadian views on the ethics of paediatric clinical trials.

    European journal of clinical pharmacology·2007
    Same author

    Update: severe acute respiratory syndrome--Toronto, 2003.

    Canada communicable disease report = Releve des maladies transmissibles au Canada·2003
    Same author

    The influence of gender and body characteristics on upright stance.

    Annals of human biology·2003
    Same author

    Prostate cancer susceptibility genes: lessons learned and challenges posed.

    Endocrine-related cancer·2003
    Same journal

    Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Composite Endpoints in Contemporary Cardiovascular Trials: Trends in Phase 3 Trials and Key Issues in Regulatory Review.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Reply to: "The Future of Clinical Pharmacology: The Right Medicine at the Right Dose for Each Patient".

    Clinical pharmacology and therapeutics·2026
    See all related articles

    Older adults exhibit altered morphine pharmacokinetics, with a smaller volume of distribution and reduced plasma clearance, potentially leading to higher drug concentrations in certain body compartments.

    Area of Science:

    • Pharmacokinetics and Drug Metabolism
    • Geriatric Pharmacology
    • Clinical Pharmacy

    Background:

    • Morphine is a widely used opioid analgesic.
    • Age-related changes can significantly alter drug pharmacokinetics.
    • Understanding morphine disposition in the elderly is crucial for safe and effective pain management.

    Purpose of the Study:

    • To compare the kinetic disposition of morphine in young versus elderly healthy subjects.
    • To investigate how age influences morphine's volume of distribution, clearance, and elimination phases.

    Main Methods:

    • A single intravenous dose of morphine (10 mg/70 kg) was administered to both young (n=13) and older (n=7) healthy subjects.
    • Pharmacokinetic parameters, including volume of distribution and plasma clearance, were analyzed.

    Related Experiment Videos

  • Morphine concentrations in different kinetic compartments were calculated over time.

    • Main Results:

    • Elderly subjects showed a significantly smaller apparent volume of distribution at steady state (half that of young subjects).
    • This reduction was attributed to decreased central and peripheral kinetic compartment volumes in older individuals.
    • While the beta elimination phase was more rapid in older adults, their plasma clearance of morphine was reduced, with higher peripheral compartment concentrations observed for 1.5 hours post-dose.

    Conclusions:

    • Age-related pharmacokinetic alterations in morphine disposition are significant.
    • Reduced volume of distribution and impaired plasma clearance in the elderly may necessitate dose adjustments.
    • These findings highlight the importance of considering age in morphine therapy to optimize patient outcomes and minimize adverse events.