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Related Experiment Videos

Sympathetic nervous system "switch off" with severe hypothermia.

B Chernow, C R Lake, A Zaritsky

    Critical Care Medicine
    |September 1, 1983
    PubMed
    Summary

    Critically ill patients experiencing hypothermia show a sympathetic nervous system (SNS) response, but this response diminishes at temperatures around 29°C. This suggests potential benefits from exogenous catecholamines in severe hypothermia.

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    Area of Science:

    • Physiology
    • Critical Care Medicine
    • Neuroendocrinology

    Background:

    • Hypothermia is common in critically ill patients.
    • The endogenous catecholamine response to hypothermia is not well understood.

    Purpose of the Study:

    • To investigate the relationship between core body temperature and the sympathetic nervous system (SNS) response during hypothermia and rewarming.
    • To measure heart rate (HR), mean arterial blood pressure (MAP), and plasma levels of norepinephrine (NE) and epinephrine (Epi) in response to decreasing and increasing core temperatures.

    Main Methods:

    • Subhuman primates (baboons) were subjected to progressive hypothermia from 37°C to 29°C, followed by rewarming to 37°C.
    • Measurements included continuous monitoring of HR and MAP.
    • Plasma NE and Epi concentrations were analyzed at various temperature points.

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    Main Results:

    • HR and MAP increased significantly as temperature decreased from 37°C to 33°C, then fell to pre-hypothermic levels as temperature dropped to 29°C.
    • Plasma NE and Epi levels significantly increased as temperature fell from 37°C to 31°C.
    • NE and Epi levels decreased towards pre-hypothermic concentrations as temperature further dropped to 29°C.

    Conclusions:

    • The SNS responds to hypothermia but appears to be inhibited at core temperatures around 29°C.
    • Hypotensive patients with core temperatures ≤29°C might benefit from exogenous catecholamine infusions if conventional therapies are insufficient.