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Related Experiment Videos

Absorption of contrast medium during ERCP.

R A Sable, W S Rosenthal, J Siegel

    Digestive Diseases and Sciences
    |September 1, 1983
    PubMed
    Summary
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    Systemic absorption of diatrizoate occurs during endoscopic retrograde cholangiopancreatography (ERCP). Higher serum levels were observed when both bile and pancreatic ducts were visualized, indicating potential contrast material reactions.

    Area of Science:

    • Gastroenterology
    • Radiology
    • Pharmacology

    Background:

    • Endoscopic retrograde cholangiopancreatography (ERCP) utilizes iodinated contrast agents.
    • Systemic absorption of these agents can lead to adverse reactions.

    Purpose of the Study:

    • To assess the systemic absorption of diatrizoate.
    • To quantify diatrizoate levels in serum and urine following ERCP.

    Main Methods:

    • Serum and urinary diatrizoate levels were measured in patients undergoing ERCP.
    • Diatrizoate was instilled into the duodenum in a subset of patients.
    • Blood and urine samples were collected at various time points post-procedure.

    Main Results:

    • Significant increases in serum diatrizoate concentrations were observed.

    Related Experiment Videos

  • Absorption varied based on the ducts visualized during ERCP.
  • Mean total urinary excretion of diatrizoate was quantified.

    • Conclusions:

    • Systemic absorption of diatrizoate is a likely event during ERCP.
    • Endoscopists should consider the potential for contrast material reactions in susceptible patients.