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Related Experiment Videos

Recovery from unilateral neglect.

R K Deuel, R C Collins

    Experimental Neurology
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Monkeys with hemisensory neglect showed spontaneous functional recovery after frontal cortex damage. This recovery correlated with restored neuronal activity in specific brain structures, suggesting a link between neural function and behavioral improvement.

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    Red and white brain.

    Annals of the New York Academy of Sciences·1998

    Area of Science:

    • Neuroscience
    • Primate behavior
    • Brain injury and recovery

    Background:

    • Hemisensory neglect is a neurological disorder characterized by a lack of awareness of stimuli on one side of space.
    • Spontaneous recovery of function is observed in some neurological conditions, but the underlying neural mechanisms are not fully understood.
    • The frontal polysensory association cortex plays a crucial role in sensory integration and attention.

    Purpose of the Study:

    • To investigate the neural mechanisms underlying spontaneous recovery from hemisensory neglect in non-human primates.
    • To identify specific brain regions and their activity patterns associated with the acute phase and recovery from neglect.
    • To explore the relationship between local glucose utilization and behavioral recovery after cortical injury.

    Main Methods:

    Related Experiment Videos

    • Unilateral operative resection of the frontal polysensory association cortex was performed in 13 macaques to induce hemisensory neglect.
    • Standardized behavioral measures were used to assess the severity and course of neglect.
    • The 2-deoxy[14C]glucose autoradiographic method was employed to measure local cerebral glucose utilization in both acute and recovery phases.

    Main Results:

    • Animals exhibited severe acute neglect following surgery.
    • In the acute phase, decrements in local glucose utilization were observed in subcortical structures, but not in cortical regions connected to the damaged area.
    • After behavioral recovery, mild decrements in glucose utilization persisted, specifically in the nucleus medialis dorsalis of the thalamus.

    Conclusions:

    • Acute hemisensory neglect symptoms are associated with widespread depression of neuronal activity in uninjured brain structures connected to the damaged cortex.
    • The return of neuronal activity in these affected structures accompanies the restitution of behavioral function.
    • Thalamic nucleus medialis dorsalis activity is implicated in the recovery process from neglect.