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Progesterone withdrawal without parturition.

M D Mitchell, S P Brennecke, D L Kraemer

    European Journal of Obstetrics, Gynecology, and Reproductive Biology
    |April 1, 1983
    PubMed
    Summary
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    Lowering progesterone in pregnant sheep with a reduced trilostane dose did not induce labor. This suggests that a significant and sustained drop in progesterone is necessary to stimulate prostaglandin synthesis for parturition.

    Area of Science:

    • Reproductive Endocrinology
    • Animal Physiology

    Background:

    • Progesterone is crucial for maintaining pregnancy in sheep.
    • Trilostane inhibits 3 beta-hydroxysteroid dehydrogenase, an enzyme involved in progesterone synthesis.

    Purpose of the Study:

    • To investigate the relationship between progesterone levels and prostaglandin biosynthesis in late-term pregnant sheep.
    • To determine if a reduced dose of trilostane could lower progesterone without inducing parturition.

    Main Methods:

    • Administration of a reduced dose (10 mg) of trilostane to 4 chronically catheterized, late-pregnant sheep.
    • Monitoring of circulating progesterone, 13,14-dihydro-15-keto-prostaglandin F2 alpha, and estradiol levels.
    • Observation for signs of parturition.

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    Main Results:

    • The 10 mg trilostane dose did not induce labor.
    • Progesterone levels decreased significantly but recovered within 24 hours.
    • A slight, transient increase in prostaglandin F2 alpha was observed, but not to levels associated with labor.
    • Estradiol levels remained unchanged.

    Conclusions:

    • Progesterone withdrawal must reach a critical magnitude and duration to sufficiently stimulate prostaglandin biosynthesis for labor induction in late gestation sheep.
    • This study provides insight into the hormonal triggers of parturition in sheep.