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Heterospecific induction of prostatic development in tissue recombinants prepared with mouse, rat, rabbit and human
Abstract:
Epithelia of embryonic urogenital sinuses (UGE) or embryonic or adult urinary bladders (BLE) were associated heterospecifically with mesenchyme of the embryonic urogenital sinus (UGM). The resultant chimeric tissue recombinants prepared with mouse, rat, rabbit, and human tissues were grown for 2 to 14 weeks in male athymic nude mice. For almost all categories of permissive (UGM + UGE) or instructive (UGM + BLE) inductions, prostatic epithelial development occurred. In recombinations of mouse UGM and human fetal BLE, the bladder epithelium was induced to form glandular structures. The morphogenetic process observed was similar to that normally expressed during human prostatic development. We conclude that the mechanism of prostatic development is similar in these mammalian species.