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[Thyroid function in patients chronically treated with amiodarone].

A Borghi, R G Gheri, E Pratesi

    Giornale Italiano Di Cardiologia
    |January 1, 1983
    PubMed
    Summary
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    Amiodarone significantly impacts thyroid function in heart disease patients, causing dysthyroidism in 22.2% of cases. The drug affects both the thyroid gland directly and peripheral thyroid hormone metabolism.

    Area of Science:

    • Endocrinology
    • Cardiology
    • Pharmacology

    Context:

    • Amiodarone is a widely used antiarrhythmic drug.
    • Thyroid dysfunction is a known side effect of amiodarone therapy.
    • Accurate assessment of thyroid hormone levels is crucial for managing patients on amiodarone.

    Purpose:

    • To investigate the effects of amiodarone on thyroid gland function in patients with heart disease.
    • To determine the prevalence and types of amiodarone-induced dysthyroidism.
    • To explore the mechanisms by which amiodarone affects thyroid hormone levels and metabolism.

    Summary:

    • A study of 45 heart disease patients treated with amiodarone revealed a 22.2% prevalence of dysthyroidism (15.6% hypothyroidism, 6.6% hyperthyroidism).
    • Amiodarone treatment altered thyroid hormone levels, with elevated T4, fT4, and rT3 in euthyroid patients and specific patterns in hypothyroid and hyperthyroid patients.

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  • The findings suggest amiodarone has both direct effects on the thyroid gland and influences peripheral thyroid hormone metabolism.

    • Impact:

    • Highlights the significant risk of thyroid dysfunction in patients receiving amiodarone.
    • Provides insights into the dual mechanism of amiodarone's action on the thyroid system.
    • Emphasizes the importance of monitoring thyroid function in patients treated with amiodarone.