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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Published on: October 3, 2025

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Duplication of the gallbladder associated with childhood obstructive biliary disease and biliary cirrhosis

E Granot, R J Deckelbaum, R Gordon

    Gastroenterology
    |October 1, 1983
    PubMed

    Insights

    A rare gallbladder duplication caused a child's biliary cirrhosis. Surgical removal of the duplicated gallbladder led to recovery, highlighting the importance of diagnosing biliary system malformations in children.

    Area of Science:

    • Pediatric Gastroenterology
    • Hepatology
    • Surgical Innovation

    Background:

    • Biliary cirrhosis in children can stem from various causes, including congenital malformations.
    • Early diagnosis and intervention are crucial for managing pediatric liver diseases.

    Observation:

    • A 4-year-old girl experienced recurrent abdominal pain, vomiting, fever, and jaundice, indicative of biliary obstruction.
    • Her condition progressed to biliary cirrhosis, suggesting a significant underlying issue.

    Findings:

    • Transhepatic cholangiography confirmed the diagnosis of gallbladder duplication, a rare congenital anomaly.
    • Surgical excision of the duplicated gallbladders resulted in clinical recovery and histological improvement.

    Implications:

    • This case underscores the necessity of investigating biliary system malformations in pediatric patients presenting with obstructive biliary disease or cirrhosis.
    • Prompt diagnosis and surgical correction of gallbladder duplication can prevent severe liver damage and improve patient outcomes.

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