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Related Experiment Videos

Renal chemoreceptors in the rat.

G M Recordati, N G Moss, L Waselkov

    Circulation Research
    |October 1, 1978
    PubMed
    Summary

    Researchers discovered novel sensory nerve fibers in rat kidneys, termed renal chemoreceptors. These receptors activate during severe renal ischemia or asphyxia, indicating a role in detecting kidney distress.

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    Area of Science:

    • Nephrology
    • Neuroscience
    • Physiology

    Background:

    • The renal nerves contain afferent fibers responsive to the kidney's internal environment.
    • Understanding these sensory pathways is crucial for comprehending renal function and pathology.

    Purpose of the Study:

    • To identify and characterize novel sensory nerve fibers in the rat kidney.
    • To investigate the functional properties of these newly identified renal sensory units.

    Main Methods:

    • Single unit recordings from dissected renal nerves in anesthetized rats.
    • Stimulation via renal artery occlusion, systemic asphyxia, pressure changes, and cyanide infusion.

    Main Results:

    • A population of sensory nerve fibers, termed renal chemoreceptors, was identified.
    • These units activated specifically during severe renal ischemia and systemic asphyxia.
    • They showed no response to alterations in systemic arterial pressure, ureteral pressure, or renal venous pressure.

    Conclusions:

    • Renal chemoreceptors represent a distinct class of renal sensory fibers, different from mechanoreceptors.
    • Their activation during ischemia suggests a role in detecting kidney chemical environment changes.
    • A kidney-derived chemical substance may activate these chemoreceptors during ischemic events.

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