Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Graphical analysis of multiple inert gas elimination data.

W E Stewart, S M Mastenbrook

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |July 1, 1983
    PubMed
    Summary

    This study introduces a graphical method using inert gases to detect lung ventilation-perfusion (V/Q) inhomogeneity. The retention-excretion (R/E) ratio plotted against reciprocal solubility quickly identifies shunt and V/Q distribution in the lungs.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prediction of forced ventilation in animal fur from a measured pressure distribution.

    Proceedings. Biological sciences·1994
    Same author

    Cancer patients' perceptions of their disease and its treatment.

    British journal of cancer·1988
    Same author

    Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model.

    Infection and immunity·1988
    Same author

    Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function.

    Journal of leukocyte biology·1988
    Same author

    Cytolytic activity of human peripheral blood leukocytes against Legionella pneumophila-infected monocytes: characterization of the effector cell and augmentation by interleukin 2.

    Journal of immunology (Baltimore, Md. : 1950)·1987
    Same author

    Induction of tumor necrosis factor by Legionella pneumophila.

    Infection and immunity·1987

    Area of Science:

    • Pulmonary Physiology
    • Gas Exchange Analysis
    • Medical Diagnostics

    Background:

    • Ventilation-perfusion (V/Q) inequality is a key factor in respiratory diseases.
    • Accurate assessment of V/Q distribution is crucial for diagnosis and management.
    • Current methods for V/Q assessment can be complex and time-consuming.

    Purpose of the Study:

    • To develop a simple graphical method for detecting shunt and V/Q inhomogeneity in the lung.
    • To establish rules for constructing a smooth retention-excretion (R/E) function from inert gas data.
    • To provide a rapid screening tool for identifying data suitable for detailed analysis.

    Main Methods:

    • Utilizing measured retention-excretion ratios (Ri/Ei)obs plotted against reciprocal solubility (1/lambda i) for inert gases.

    Related Experiment Videos

  • Applying a multicompartmental lung model to derive R/E function rules.
  • Analyzing the derivatives of the R/E function with respect to 1/lambda i to characterize V/Q distribution.

    • Main Results:

    • A plot of (Ri/Ei)obs vs. 1/lambda i allows for rapid detection of shunt and V/Q inhomogeneity.
    • The shape of the R/E function (rectilinear or concave) indicates the breadth of V/Q distribution.
    • Shunt and dead-space ventilation can be estimated from the function's asymptotes.

    Conclusions:

    • The R/E vs. 1/lambda graph serves as an effective preliminary tool for lung V/Q assessment.
    • This graphical method simplifies the initial evaluation of inert gas data.
    • It helps determine the necessity of more complex numerical analysis for V/Q evaluation.