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Acrodermatitis enteropathica.

D M Bronson, R Barsky, S Barsky

    Journal of the American Academy of Dermatology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    A rare case of acrodermatitis enteropathica (AE) in pregnancy highlights its importance. Prompt zinc sulfate treatment resolved severe skin lesions, emphasizing AE in the differential diagnosis for pregnant women.

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    Area of Science:

    • Dermatology
    • Obstetrics
    • Human Genetics

    Background:

    • Acrodermatitis enteropathica (AE) is a rare genetic disorder of zinc absorption.
    • It typically presents in infancy but can have late-onset or intermittent forms.
    • Pregnancy can unmask or exacerbate underlying conditions due to physiological changes.

    Observation:

    • A 23-year-old pregnant woman presented with recurrent pustular, vesiculobullous, and psoriasiform dermatoses.
    • These lesions, absent during childhood and puberty, reappeared during two pregnancies.
    • Initial diagnoses included herpes gestationis and impetigo herpetiformis.

    Findings:

    • Markedly decreased serum zinc levels (18 µg/dL) were identified.
    • Treatment with zinc sulfate led to rapid improvement of cutaneous lesions within 3 days.

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  • Postpartum, lesions resolved completely with normalized zinc levels.
  • Implications:

    • Acrodermatitis enteropathica should be considered in the differential diagnosis of unresponsive bullous dermatoses during pregnancy.
    • Timely zinc level assessment and supplementation can effectively manage AE flares.
    • This case underscores the importance of recognizing AE in pregnant women with unexplained dermatological conditions.