Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children
View abstract on PubMed
Summary
This summary is machine-generated.Certain asthmatic children may experience harmful effects from antihistamines. Brompheniramine maleate and combination decongestant-antihistamines significantly decreased pulmonary function in a subset of children studied.
Area Of Science
- Pediatric Pulmonology
- Allergy and Immunology
- Pharmacology
Background
- The safety and efficacy of antihistamines in pediatric asthma management remain debated.
- Previous research yielded conflicting results regarding antihistamine use in asthmatic patients.
Purpose Of The Study
- To investigate the potential adverse effects of antihistamines on pulmonary function in children with asthma.
- To identify a specific subset of asthmatic children who may be negatively impacted by antihistamine therapy.
Main Methods
- A challenge study involving 10 asthmatic children reporting adverse reactions to brompheniramine maleate and 10 controls.
- Pulmonary function tests were conducted after administration of brompheniramine maleate, a decongestant-antihistamine combination, and placebo.
- Theophylline premedication was used in the study group to assess its protective effect.
Main Results
- A statistically significant decline in pulmonary function was observed in the study group when challenged with brompheniramine maleate and the decongestant-antihistamine preparation.
- No significant changes in pulmonary function were noted in the control group or in the study group when given placebo.
- Theophylline premedication successfully prevented the decrease in pulmonary function in the study group.
Conclusions
- A distinct subgroup of asthmatic children exists for whom antihistamine use, specifically brompheniramine maleate, may be detrimental.
- These findings suggest that caution is warranted when prescribing antihistamines to certain pediatric asthma patients.
- Theophylline may serve as a prophylactic measure against antihistamine-induced bronchoconstriction in susceptible individuals.