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Testing for hepatitis B virus in patients with chronic urticaria and angioedema

G A Vaida, M A Goldman, K J Bloch

    The Journal of Allergy and Clinical Immunology
    |August 1, 1983
    PubMed

    Insights

    Hepatitis B virus (HBV) infection markers were found in 17.6% of chronic urticaria and angioedema (CUA) patients, a significantly higher rate than the general population. This suggests a potential link between HBV and CUA requiring further investigation.

    Area of Science:

    • Hepatology
    • Immunology
    • Dermatology

    Background:

    • Chronic urticaria and angioedema (CUA) is a complex condition with multifactorial etiologies.
    • Hepatitis B virus (HBV) infection is a significant global health concern.
    • Investigating potential infectious triggers for chronic inflammatory conditions is crucial.

    Observation:

    • Serologic markers for HBV infection were assessed in 114 patients diagnosed with CUA.
    • Serum samples from 85 (75%) of these patients were analyzed for HBV markers.
    • The study aimed to determine the prevalence of HBV infection within this patient cohort.

    Findings:

    • HBV infection markers were detected in 15 (17.6%) of the CUA patients.
    • Specifically, 13 patients (15.3%) showed evidence of past HBV infection (anti-HBs), and 2 patients (2.4%) had active infection (HBsAg).
    • The prevalence of HBV infection in CUA patients was notably higher than in the general population.

    Implications:

    • The findings suggest a potential association between HBV infection and the development or exacerbation of CUA.
    • The two patients with HBsAg also received a diagnosis of chronic persistent hepatitis, highlighting a direct health consequence.
    • Further research is warranted to elucidate the causal relationship, if any, between HBV infection and CUA.

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