Related Experiment Video
Updated: Aug 7, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Nervous tension and serum cholesterol: findings from the Chicago Coronary Prevention Evaluation Program
Insights
Experiencing tension, even mild, was linked to higher serum cholesterol levels in middle-aged men. This finding suggests stress management may be important for cardiovascular health.
Area of Science:
- Cardiovascular Health
- Psychosomatic Medicine
- Preventive Cardiology
Background:
- Coronary-prone individuals are at increased risk for cardiovascular events.
- Psychological factors like tension can influence physiological health.
- Understanding the impact of tension on biomarkers is crucial for prevention.
Purpose of the Study:
- To investigate the relationship between self-perceived tension and serum cholesterol levels.
- To determine if this relationship is independent of other health factors.
Main Methods:
- Analysis of data from 519 coronary-prone middle-aged men in the Chicago Coronary Prevention Evaluation Program.
- Self-reported tension levels (none, slight, moderate, marked) were recorded.
- Serum cholesterol levels were measured and compared between tension and no-tension groups.
Main Results:
- A statistically significant elevation of approximately 4 mg/dl in mean serum cholesterol was observed in men reporting tension compared to those reporting no tension.
- This association remained consistent regardless of weight changes, infections, medication use, or time of year.
Conclusions:
- Self-perceived tension is associated with higher serum cholesterol in coronary-prone men.
- Tension may be an independent risk factor for elevated cholesterol, impacting cardiovascular health.
Abstract:
Of 519 coronary-prone middle-aged men participating in the Chicago Coronary Prevention Evaluation Program, 416 reported their self-perceived state as one of no tension or tension at various periodic visits over years in the Program. Group mean serum cholesterol was significantly higher by about 4 mg/dl with tension vs. no tension (slight, moderate, or marked). This relationship was independent of weight change, intercurrent infection, use of medication, and month of year.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Coronary Artery Disease IV: Preventive Measures
Acute Coronary Syndrome III: Diagnostic Studies
Hypertension III: Clinical Manifestations and Diagnostic Studies

