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Related Experiment Videos

Visual evoked responses in diabetes.

K Puvanendran, G Devathasan, P K Wong

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1983
    PubMed
    Summary
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    Diabetic optic neuropathy is more common than previously thought, affecting over 80% of diabetics. This study reveals early optic nerve damage in diabetes, even with normal vision.

    Area of Science:

    • Ophthalmology
    • Neurology
    • Diabetology

    Background:

    • Diabetic optic neuropathy is considered rare, with vision loss often attributed to other diabetic complications.
    • Subclinical optic nerve dysfunction in diabetes has been understudied due to a lack of sensitive diagnostic tools.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of optic nerve involvement in diabetic patients without retinopathy or other ocular diseases.
    • To assess subclinical optic nerve affection using visual evoked potentials (VEPs).

    Main Methods:

    • Utilized pattern reversal visual evoked responses (VEPs) to evaluate optic nerve function.
    • Compared VEPs in 16 diabetic patients (no retinopathy/ocular disease, normal visual acuity) with 35 healthy controls.

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    Main Results:

    • 81% of diabetic patients showed increased VEP latency ( >1 SD), and 62.5% showed significantly slowed conduction ( >3 SD).
    • Reduced VEP amplitude was frequently observed alongside latency changes.
    • A correlation was found between optic nerve conduction and peripheral sensory nerve function, but not duration or glycemic control (except possibly in juvenile-onset diabetes).

    Conclusions:

    • Subclinical optic nerve abnormalities are prevalent in diabetes, even with preserved visual acuity.
    • VEP testing demonstrates early, widespread optic nerve dysfunction in diabetes.
    • The high rate of VEP abnormalities in diabetes may impact its utility in diagnosing other neurological conditions like multiple sclerosis.