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Fluoride balances during early and late pregnancy
Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
|August 1, 1983
Summary
Pregnancy does not significantly alter fluoride metabolism. This study found similar fluoride excretion and retention in pregnant and non-pregnant women, suggesting occupational fluoride exposure may not pose unique risks during pregnancy.
Area of Science:
- Human Physiology
- Environmental Health
- Toxicology
Background:
- Limited data exists on occupational fluoride exposure risks for pregnant women.
- Understanding fluoride metabolism during pregnancy is crucial for risk assessment.
Purpose of the Study:
- To investigate fluoride excretion and balance in pregnant and non-pregnant women.
- To assess potential alterations in fluoride metabolism during different stages of pregnancy.
Main Methods:
- Metabolic study involving 18 women (non-pregnant, early, and late pregnancy).
- Controlled 20-day period measuring total fluoride intake, urinary, and fecal excretion.
- Calculation of fluoride balance and statistical analysis of group differences.
Main Results:
- Average daily fluoride intake was 1.35 mg/day.
- Urinary fluoride excretion levels were similar across all groups (0.95-1.15 mg/day).
- Small, non-statistically significant positive fluoride balances were observed in all groups.
Conclusions:
- Fluoride metabolism appears largely unchanged throughout pregnancy.
- Pregnancy does not significantly alter fluoride excretion or retention.
- Findings suggest occupational fluoride exposure may not present unique risks to pregnant women.
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