Inhibited female orgasm resulting from psychotropic drugs. A clinical review

Female orgasm inhibition associated with psychotropic agents was reported ten years after the first report of ejaculatory disturbance in the male resulting from psychotropic drugs. To date, the psychotropic agents that have been reported to inhibit female orgasm include antipsychotic agents (thioridazine and trifluoperazine), monoamine oxidase inhibitors (phenelzine, isocarboxazid and tranylcypromine) and tricyclic antidepressants (amoxapine, clomipramine and amitriptyline). As awareness of this sexual side effect of psychotropic drugs grows, more drugs undoubtedly will be added to the list. Physicians should be alert to the underreporting of sexual side effects by female patients and should solicit such information from them.