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Myocardial involvement in polymyositis.

S L Strongwater, T Annesley, T J Schnitzer

    The Journal of Rheumatology
    |June 1, 1983
    PubMed
    Summary
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    Polymyositis patients frequently experience cardiac issues, with 83% showing elevated creatine kinase-MB (CK-MB) levels. This suggests significant myocardial involvement in polymyositis, often undetected by current methods.

    Area of Science:

    • Cardiology
    • Neurology
    • Immunology

    Background:

    • Polymyositis (PM) is a myopathic syndrome primarily affecting skeletal muscle.
    • Cardiac involvement in PM is suspected but often clinically underestimated.
    • Serum creatine kinase (CK) and its MB isoenzyme (CK-MB) are markers for myocardial injury.

    Observation:

    • A retrospective study analyzed 12 patients diagnosed with polymyositis.
    • Quantitative determinations of serum CK and CK-MB activity were assessed.
    • Clinical presentation and diagnostic findings were reviewed.

    Findings:

    • 83% (10 out of 12) of polymyositis patients exhibited substantial elevations in CK-MB activity.
    • Elevated CK-MB levels in PM patients sometimes surpassed levels seen in myocardial infarctions.

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  • This indicates a high probability of myocardial involvement in polymyositis.

    • Implications:

    • The high prevalence of elevated CK-MB suggests current diagnostic technology may be insensitive to cardiac involvement in PM.
    • Recognizing the spectrum and frequency of cardiac issues in PM is crucial.
    • Potential functional consequences include conduction disturbances and cardiomyopathy, necessitating further clinical attention.