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Steroid secretion by the prepubertal human testis.

M Serio, G Forti, F Facchinetti

    Journal of Steroid Biochemistry
    |July 1, 1983
    PubMed
    Summary
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    The human prepubertal testis secretes testosterone and progesterone, with higher levels found in spermatic blood compared to peripheral blood. This indicates a distinct testicular secretory pattern in prepubertal boys compared to adults.

    Area of Science:

    • Endocrinology
    • Pediatric Endocrinology
    • Reproductive Endocrinology

    Background:

    • The human testis is known to secrete androgens like testosterone and androstenedione.
    • Understanding testicular function in prepubertal boys is crucial for diagnosing and managing conditions affecting reproductive health.

    Purpose of the Study:

    • To investigate the specific steroid hormone secretion patterns of the human prepubertal testis.
    • To compare the levels of testosterone, progesterone, 17 alpha-hydroxyprogesterone, and 20 alpha-dihydroprogesterone in spermatic and peripheral venous blood of prepubertal boys.

    Main Methods:

    • Hormone levels (testosterone, progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-dihydroprogesterone) were measured in spermatic and peripheral venous blood samples.
    • Samples were collected from prepubertal boys undergoing surgery for undescended testis or inguinal hernia repair.

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  • Statistical analysis was performed to compare spermatic and peripheral hormone levels.

    • Main Results:

    • Significantly higher levels of testosterone and progesterone were observed in spermatic plasma compared to peripheral plasma.
    • No significant difference in spermatic-peripheral gradient was found for 17 alpha-hydroxyprogesterone and 20 alpha-dihydroprogesterone.
    • These findings highlight a unique steroidogenic profile in the prepubertal testis.

    Conclusions:

    • The human prepubertal testis exhibits a distinct secretory pattern of steroid hormones, differing from adult testicular function.
    • Testosterone and progesterone are key hormones secreted by the prepubertal testis, with preferential release into the spermatic circulation.
    • Further research is warranted to elucidate the implications of these findings for male reproductive development and health.