Noncardiogenic pulmonary edema following blood transfusion

Noncardiogenic pulmonary edema and acute respiratory failure were found to develop after blood transfusion. Pulmonary antiographic studies and hemodynamic measurements were performed in the presence of pulmonary edema. Normal wedge pressure was observed at the time of angiographic studies, and contrast material appeared to extravasate across the alveolocapillary membrane into the alveoli. The mechanisms of acute injury to the alveolocapillary membranes and of pulmonary edema secondary to reactions to transfusion are discussed.