Prediction of cimetidine disposition in the aged

The change in the elimination half-life of cimetidine as a function of age can accurately be predicted by an equation previously published. For the age-dependent change of the apparent volume of distribution a correction factor was developed based on total body fluid and body fat as a function of age. The predicted values correlate well with experimental data reported. Consequently, a computer program was developed for cimetidine dosage regimen prediction which can be used for "normal" subjects, young and geriatric patients without and with renal impairment.