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Enkephalin-binding systems in human plasma.

R Possenti, V De Marco, O Cherubini

    Neurochemical Research
    |April 1, 1983
    PubMed
    Summary

    Human plasma contains substances that bind enkephalins, potentially preserving their function. These include serum albumin and two low molecular weight polypeptides, which together bind most circulating enkephalins.

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    Area of Science:

    • Biochemistry
    • Neuroscience
    • Proteomics

    Background:

    • Enkephalins are endogenous opioid peptides involved in pain modulation and mood regulation.
    • The circulating forms and binding proteins of enkephalins in human plasma are not fully characterized.

    Purpose of the Study:

    • To identify and characterize plasma components that bind leu-enkephalin and met-enkephalin.
    • To investigate the potential role of these binding interactions in regulating enkephalin integrity.

    Main Methods:

    • Plasma fractionation techniques to isolate binding components.
    • Binding assays to quantify enkephalin association with different fractions.

    Main Results:

    • Three distinct fractions in human plasma bind leu- and met-enkephalin.
    • Serum albumin binds enkephalins, but two lower molecular weight polypeptide fractions exhibit higher binding capacity.
    • These low molecular weight systems collectively bind a significant portion of circulating enkephalins.

    Conclusions:

    • Human plasma contains multiple systems, primarily low molecular weight polypeptides, that bind circulating enkephalins.
    • These binding interactions may be crucial for maintaining the stability and integrity of enkephalins in circulation.

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