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Halothane induced porcine malignant hyperthermia reversed by dantrolene
Nordisk Veterinaermedicin
|May 1, 1983
Summary
Malignant hyperthermia (MH) in pigs undergoing Halothane anesthesia was reversed by Dantrolene. This treatment shows promise for stress-susceptible pigs experiencing MH symptoms.
Area of Science:
- Veterinary Anesthesiology
- Pharmacology
- Animal Science
Background:
- Malignant hyperthermia (MH) is a severe hypermetabolic crisis.
- Halothane anesthesia can trigger MH in susceptible individuals.
- Porcine models are crucial for studying MH.
Purpose of the Study:
- To investigate the efficacy of Dantrolene in reversing Halothane-induced Malignant hyperthermia in pigs.
- To evaluate Dantrolene's effect on serum lactate levels during MH episodes.
Main Methods:
- Six littermate pigs underwent Halothane anesthesia.
- Three pigs exhibited Malignant hyperthermia.
- Intravenous Dantrolene was administered at 2 or 3 mg/kg to affected pigs.
Main Results:
- Dantrolene successfully reversed MH symptoms in two out of three pigs.
- Transient reversal of MH symptoms was observed in one pig after Dantrolene administration.
- Serum lactate levels remained elevated despite Dantrolene treatment in MH-positive pigs.
Conclusions:
- Dantrolene is an effective therapeutic agent for reversing Malignant hyperthermia in susceptible pigs.
- Dantrolene's efficacy may be dose-dependent or influenced by other factors.
- Further research is needed to understand Dantrolene's impact on metabolic parameters during MH.