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Hypothalamic GABA system and plasma corticosterone in ether stressed rats.

H Manev, D Pericić

    Pharmacology, Biochemistry, and Behavior
    |June 1, 1983
    PubMed
    Summary

    Ether stress activates the hypothalamic GABA system in rats, increasing glutamate decarboxylase (GAD) activity. This stress response helps prevent further activation of the hypothalamo-hypophyseal-adrenal (HHA) axis.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Stress Physiology

    Background:

    • The hypothalamo-hypophyseal-adrenal (HHA) axis is a key stress response system.
    • The gamma-aminobutyric acid (GABA) system in the hypothalamus plays a role in regulating stress.

    Purpose of the Study:

    • To investigate the effect of ether stress on the hypothalamic GABA system and its interaction with the HHA axis.
    • To understand how GABAergic transmission influences the stress response.

    Main Methods:

    • Rats were exposed to ether stress.
    • Plasma corticosterone levels were measured.
    • Hypothalamic GABA levels, GABA synthesis (GAD activity), and GABA catabolism (GABA-T activity) were assessed.
    • The effects of diazepam on the stress response were evaluated.

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    Main Results:

    • Ether stress increased plasma corticosterone and affected hypothalamic GABA metabolism.
    • GABA accumulation induced by AOAA or L-cycloserine decreased, while GAD activity increased.
    • GABA concentration and GABA-T activity remained unchanged.
    • Diazepam potentiated corticosterone release but blunted the stress-induced increase.

    Conclusions:

    • Ether stress activates the hypothalamic GABA system.
    • Despite decreased GABA accumulation, the activated GABA system may play a role in limiting the HHA axis response to stress.
    • GABAergic modulation influences the HHA axis's reaction to acute stress.