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Related Experiment Videos

Increased consumption of diazepam during continuous amphetamine administration.

L R Nelson, A D Potthoff, G D Ellison

    Pharmacology, Biochemistry, and Behavior
    |June 1, 1983
    PubMed
    Summary

    d-amphetamine administration significantly increased diazepam consumption in female rats, indicating a potential drug interaction affecting substance intake behaviors. This highlights how stimulant drugs can alter the preference for other substances.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Previous studies showed d-amphetamine increases ethanol consumption in rats.
    • This suggests stimulants may influence the intake of other psychoactive substances.

    Purpose of the Study:

    • To investigate if d-amphetamine affects benzodiazepine (diazepam) consumption.
    • To determine the impact of stimulant drugs on the intake of sedative-hypnotic drugs.

    Main Methods:

    • Female albino rats were provided access to water and a diazepam solution.
    • Fluid intake was monitored before and after implantation of slow-release d-amphetamine pellets.
    • Control groups received vehicle-only pellets.

    Main Results:

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    • Baseline diazepam consumption averaged 25% of total fluid intake.
    • d-amphetamine treatment increased diazepam consumption to 48% of total fluid intake.
    • Control groups showed no significant change in diazepam consumption.

    Conclusions:

    • d-amphetamine selectively increases the consumption of diazepam solutions in rats.
    • This finding suggests a potential interaction between stimulants and benzodiazepines affecting substance-seeking behavior.
    • Further research is warranted to explore the neurobiological mechanisms underlying this effect.