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Related Experiment Videos

Immunoglobulin deficiency in gastrointestinal allergies.

J D Gryboski, S Kocoshis

    Journal of Clinical Gastroenterology
    |March 1, 1980
    PubMed
    Summary

    This study investigated pediatric gastrointestinal allergies, finding common combined sensitivities to milk, soy, and gluten. A significant portion of children with milk allergy exhibited immunoglobulin abnormalities, a novel finding in allergic gastroenteritis.

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    Area of Science:

    • Pediatric Allergy and Immunology
    • Gastroenterology
    • Immunology

    Background:

    • Gastrointestinal allergies are common in infants and children.
    • Understanding the interplay of food sensitivities and immune responses is crucial.
    • Previous research has not fully elucidated the incidence of immunoglobulin abnormalities in allergic gastroenteritis.

    Purpose of the Study:

    • To investigate multiple gastrointestinal allergies in a cohort of 98 infants and children.
    • To identify common combined food sensitivities.
    • To explore the association between clinical presentation, family history, prior infections, and immunoglobulin disorders.

    Main Methods:

    • Retrospective analysis of 98 pediatric patients with diagnosed gastrointestinal allergies.

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  • Categorization of patients based on combined food sensitivities (milk, soy, gluten).
  • Clinical data review including age of onset, diarrhea characteristics, family history, and history of infections.

    • Main Results:

    • Combined milk and soy sensitivity was most prevalent (61 cases), followed by soy and gluten (34 cases).
    • Two distinct clinical groups emerged: early-onset diarrhea in infants and chronic diarrhea post-gastroenteritis in young children.
    • Nearly half of milk-allergic infants and a third of all participants showed transient or late-onset immunoglobulin disorders.

    Conclusions:

    • Milk, soy, and gluten are common co-allergens in pediatric gastrointestinal allergies.
    • Clinical presentation varies, with distinct patterns in early-onset vs. post-infectious cases.
    • A high incidence of immunoglobulin abnormalities is associated with allergic gastroenteritis, particularly in milk-allergic infants.