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Elastofibroma. A correlated light and electron microscopic study.

L G Kindblom, S S Spicer

Virchows Archiv. A, Pathological Anatomy and Histology

|January 1, 1982

Summary

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Elastofibromas are benign growths characterized by collagen and abundant elastin. Ultrastructural analysis suggests they are reactive lesions, not tumors, with stromal cells synthesizing elastin.

Area of Science:

Pathology
Histology
Electron Microscopy

Background:

Elastofibroma is a rare soft tissue tumor typically found in the subscapular region.
Its exact nature and origin have been debated, with varying theories on its development.

Observation:

This study reports four cases of subscapular elastofibroma in elderly patients.
Light and electron microscopy, including Verhoeff's iron-hematoxylin (VIH)-stained sections, were used for detailed analysis.
Microscopic examination revealed connective tissue with collagen, sclerotic masses, and abundant elastin fibers and globules.

Findings:

Elastin fibers exhibited a unique 'necklace-like' appearance in Epon sections.
Ultrastructural examination indicated that elastin material is synthesized by stromal cells.

Related Experiment Videos

The findings suggest elastofibroma is a reactive, non-neoplastic lesion, with elastin deposition around existing fibers.

Implications:

This research clarifies the histogenesis of elastofibroma, identifying it as a reactive process.
Understanding the reactive nature of elastofibroma is crucial for accurate diagnosis and management.
The study highlights the utility of ultrastructural analysis in characterizing soft tissue lesions.