Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat.

W A Pulsinelli, S Waldman, D Rawlinson

    Neurology
    |November 1, 1982
    PubMed
    Summary

    Hyperglycemia, or high blood sugar, before or during brain ischemia significantly worsens brain damage and edema in rats. Glucose administration exacerbated neuronal injury and swelling compared to saline or mannitol treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Achieving net zero in a cluttered seascape: Policy gaps, conflicts and synergies.

    Marine pollution bulletin·2026
    Same author

    The skeletal consequences of epidural steroid injections: a literature review.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    Impact of a physician - critical care practitioner pre-hospital service in Wales on trauma survival: a retrospective analysis of linked registry data.

    Anaesthesia·2021
    Same author

    Development of a registration framework to validate MRI with histology for prostate focal therapy.

    Medical physics·2015
    Same author

    Improving Multiple Sclerosis Plaque Detection Using a Semiautomated Assistive Approach.

    AJNR. American journal of neuroradiology·2015
    Same author

    Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector.

    Physical review letters·2011

    Area of Science:

    • Neuroscience
    • Pathology
    • Biochemistry

    Background:

    • Ischemic stroke is a leading cause of death and disability worldwide.
    • Understanding factors that exacerbate brain damage during ischemia is crucial for developing effective treatments.
    • Hyperglycemia is a common condition in stroke patients and its impact on ischemic brain injury is a significant concern.

    Purpose of the Study:

    • To investigate the effects of glucose administration on ischemic brain damage and brain edema.
    • To compare the neuroprotective potential of glucose, saline, and mannitol in a rat model of global cerebral ischemia.

    Main Methods:

    • A four-vessel occlusion (4-VO) rat model was used to induce global cerebral ischemia.
    • Rats received injections of glucose, saline, or mannitol before, during, or after the ischemic period.

    Related Experiment Videos

  • Brain damage and water content were assessed morphologically and quantitatively.

    • Main Results:

    • Glucose administration prior to ischemia resulted in severe neocortical neuronal necrosis, widespread forebrain damage, and significant brain edema.
    • Saline injection led to only scattered ischemic damage with no increase in brain water content.
    • D-glucose administration before or during ischemia exacerbated morphologic damage in the cerebellum.

    Conclusions:

    • Hyperglycemia significantly augments morphologic brain damage when it precedes or coincides with severe forebrain or moderate hindbrain ischemia.
    • These findings highlight the detrimental role of hyperglycemia in ischemic stroke.
    • Glucose management may be a critical therapeutic target in stroke patients.