Dopamine sensitive adenylate cyclase inactivation by organolead compounds

Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyclase is shown to be inhibited by trisubstituted organolead compounds as a consequence of competition with dopamine for the DA-1 receptor.