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[Biochemical indicators of malnutrition in children with intrauterine growth retardation]
Revista Espanola De Fisiologia
|January 1, 1982
Insights
Malnourished "small for dates" newborns show altered plasma and urine amino acids. Nutritional intervention normalized these levels within 7 days, indicating effective dietary management for intrauterine growth restriction.
Area of Science:
- Biochemistry
- Neonatology
- Nutritional Science
Context:
- "Small for dates" newborns, also known as small for gestational age (SGA) infants, often exhibit signs of intrauterine growth restriction.
- Assessing amino acid profiles in plasma and urine provides insights into the nutritional status and metabolic health of these vulnerable infants.
Purpose:
- To investigate the dynamic changes in plasma and urine amino acid profiles in "small for dates" newborns during the first month of life.
- To evaluate the impact of a specific dietary intervention on correcting observed amino acid imbalances and indicators of malnutrition.
Summary:
- "Small for dates" newborns presented with lower plasma albumin levels and altered plasma amino acid patterns indicative of malnutrition compared to controls.
- Urinary excretion of histidine and its N-methyl derivatives was significantly lower in "small for dates" infants.
- The implemented dietary regimen successfully normalized all measured biochemical and nutritional indexes within 7 days of life.
Impact:
- Demonstrates the utility of plasma and urine amino acid analysis in diagnosing and monitoring malnutrition in "small for dates" newborns.
- Highlights the rapid efficacy of nutritional support in reversing biochemical markers of malnutrition in this population.
- Provides evidence for optimized dietary strategies to improve outcomes for infants with intrauterine growth restriction.
Abstract:
The evolution of plasma and urine amino acids in "small for dates" newborns from the first hours of life to 30 days has been studied. The results obtained point out the occurrence of malnutrition in these newborns who have lower levels of plasma albumin than controls, high indexes of malnutrition from plasma aminograms and lower urinary excretion of histidine and its N-methyl derivatives. All indexes are normalized at 7 days of life with the used diet.