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Related Experiment Videos

Dynamic ventriculography with K-strophantin.

F Cucchini, M di Donato, R Ferrari

    European Journal of Cardiology
    |August 1, 1978
    PubMed
    Summary

    K-strophantin demonstrated varied effects on coronary artery disease (CAD) patients, improving some asynergic heart muscle areas while worsening others. This suggests K-strophantin may help assess digitalis therapy effectiveness and myocardial reserve in CAD.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Coronary artery disease (CAD) often impairs left ventricular function.
    • Assessing myocardial viability and contractile reserve is crucial for guiding therapy in CAD patients.

    Purpose of the Study:

    • To evaluate the effects of K-strophantin on ventricular function in patients with CAD.
    • To determine if the 'strophantin test' can predict response to digitalis therapy and assess residual contractile reserve.

    Main Methods:

    • Dynamic ventriculography was performed before and after K-strophantin administration (0.008 mg/kg) in 14 CAD patients.
    • Qualitative and quantitative hemodynamic and angiographic data were analyzed.
    • Changes in segmental systolic shortening and ejection fraction were assessed.

    Main Results:

    • K-strophantin showed differential effects on asynergic myocardial regions: 54% improved, 34% worsened or became akinetic.
    • Improvement correlated with viable myocardium; worsening suggested fibrosis.
    • Ventricular function improvements were primarily observed in the first half of ejection.

    Conclusions:

    • K-strophantin can elicit distinct responses in different myocardial regions of CAD patients, indicating potential for assessing digitalis therapy efficacy.
    • The 'strophantin test' may be valuable for determining residual contractile reserve and predicting therapeutic response in CAD.
    • Observed changes suggest a direct inotropic effect of K-strophantin on the left ventricle.

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