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Related Experiment Videos

[Plasma corticosterone concentration in morphine-dependent rats].

T Suzuki, M Shimada, T Yoshii

    Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Morphine administration via drug-admixed food increases plasma corticosterone in rats. Tolerance to this effect does not develop within four weeks, and this method induces morphine dependence without disrupting circadian rhythms.

    Area of Science:

    • Pharmacology
    • Neuroendocrinology

    Context:

    • Morphine is a potent opioid analgesic with significant physiological effects.
    • Understanding morphine's impact on the hypothalamic-pituitary-adrenal (HPA) axis is crucial for managing opioid use and dependence.
    • The drug-admixed food method offers a novel approach to chronic drug administration in animal models.

    Purpose:

    • To investigate the effects of chronic morphine administration via drug-admixed food on plasma corticosterone levels in rats.
    • To determine if tolerance develops to morphine-induced elevations in corticosterone.
    • To assess the impact of this administration method on the circadian rhythm of corticosterone and the induction of morphine dependence.

    Summary:

    • Rats administered morphine through drug-admixed food exhibited dose-dependent increases in plasma corticosterone.

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  • Significant elevations in corticosterone were observed even at 9:00 AM, suggesting a potential disruption of circadian rhythm.
  • Morphine dependence was induced, evidenced by increased corticosterone post-naloxone administration and withdrawal, with no tolerance observed up to four weeks.

    • Impact:

    • The drug-admixed food method effectively induces morphine dependence while maintaining circadian rhythm integrity.
    • Findings suggest that tolerance to morphine's effect on corticosterone does not develop within a four-week treatment period.
    • This study provides valuable insights into opioid-induced HPA axis dysregulation and offers a practical model for addiction research.