Post-stress development and healing of supine-restraint induced stomach lesions in the rat

In Experiment 1, rats were subjected to 3 hr of supine restraint and sacrificed either immediately, 30, 60, 90, 120 or 180 min following restraint. Rats sacrificed 90 min after restraint revealed significantly more stomach lesions as compared to other treatment conditions. The healing rate for supine-restraint ulcers was observed in Experiment 2 and comparisons with conventional restraint procedures, as reported in other publications, would suggest a slower healing rate for lesions induced with supine restraint. Experiment 3 indicated that cimetidine significantly accelerated the rate of healing for supine-restraint lesions.