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Related Experiment Videos

Bronchoconstriction caused by Florida red tide toxins.

D G Baden, T J Mende, G Bikhazi

    Toxicon : Official Journal of the International Society on Toxinology
    |January 1, 1982
    PubMed
    Summary

    Toxin T17 from Ptychodiscus brevis causes airway constriction in guinea pigs. This effect was blocked by atropine, suggesting a muscarinic mechanism, but not by vagal nerve or diaphragm manipulation.

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    Area of Science:

    • Marine biology
    • Toxicology
    • Physiology

    Background:

    • Red tide events caused by Ptychodiscus brevis can release toxins.
    • Ptychodiscus brevis toxins may pose respiratory health risks.

    Purpose of the Study:

    • To investigate the physiological effects of T17 toxin on respiratory function.
    • To determine the mechanism of T17-induced bronchoconstriction.

    Main Methods:

    • T17 toxin was purified from Ptychodiscus brevis.
    • Bronchoconstriction was induced in anesthetized, artificially-ventilated guinea pigs.
    • Respiratory resistance was measured during mechanical pulmonary inflation.
    • The effects of atropine and vagal nerve stimulation interruption were assessed.

    Main Results:

    • Toxin T17 induced significant bronchoconstriction in guinea pigs.
    • Atropine effectively antagonized the T17-induced bronchoconstriction.
    • Interruption of vagal nerve stimulation did not affect the T17-induced bronchoconstriction.

    Conclusions:

    • T17 toxin from Ptychodiscus brevis causes bronchoconstriction.
    • The mechanism of T17-induced bronchoconstriction involves muscarinic receptors.
    • Toxin T17 poses a potential respiratory hazard.

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