[Memantine and neurogenic bladder disorders within the bounds of spastic conditions]

The action of 1,3-dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) on neurogenic bladder dysfunction in spastic conditions was investigated. Under memantine treatment micturition was considerably facilitated, and spontaneous, involuntary voiding reduced. Additionally, memantine effected a decrease of residual urine and toned down the vesicular sphincter by simultaneously enhancing detrusor activity. At the same time the patients reported a considerable diminution of spastic hypertonicity and improved mobility of the limb muscles.