Studies on the formative mechanism of mesangiolytic changes of renal glomerulus induced by a low calcium diet...

Mucopolysaccharides (MPS) are widely distributed in the connective tissues throughout the animal body. There are a lot of MPS classified both chemically and immunochemically and solutions of these various polysaccharides are characterized physicochemically by their high viscosity. In this study guinea pigs were bred on a low calcium diet of 0.2% for 13 weeks and the mesangiolytic changes of renal glomerulus--the partial cystic dilatation of the glomerular tufts with edematous loosening of the mesangial tissue were shown light microscopically. The less dense mesangial matrix with prominence of mesangial fibrils and small cytoplasmic projections of the mesangial cells were demonstrated electron microscopically. The formative mechanism of these mesangiolytic changes of renal glomerulus induced by a low calcium diet breeding will be discussed in this paper.