Basal cell adenoma with acinic differentiation

Area of Science:

• Pathology
• Oncology
• Head and Neck Surgery

Background:

• Basal cell adenoma is a rare benign salivary gland neoplasm.
• It most commonly occurs in the parotid gland.
• Understanding its histological and ultrastructural features is crucial for diagnosis.

Observation:

• A case of basal cell adenoma in the left parotid region of a 45-year-old male is presented.
• The tumor measured 1.1 cm x 0.9 cm, was spherical, and encapsulated.
• Histological examination revealed monomorphic adenoma with solid, trabecular, tubular, and acinic structures.

Findings:

• Tumor cells secreted a periodic acid-Schiff (PAS)-positive substance.
• Electron microscopy identified secretory, non-secretory, and myoepithelial cells.
• Acinar and tubular structures were lined by secretory cells, with myoepithelial cells at the base.

Implications:

• This detailed case study contributes to the literature on basal cell adenoma.
• It highlights the characteristic histological and ultrastructural findings.
• Accurate diagnosis aids in appropriate clinical management of parotid gland tumors.