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Depression and hostility in hyperprolactinemia.

M Fava, G A Fava, R Kellner

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1982
    PubMed
    Summary
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    Hyperprolactinemia in women is linked to increased hostility, depression, and anxiety. These psychological effects were more pronounced than in women with amenorrhea or postpartum women, but not observed in males.

    Area of Science:

    • Endocrinology
    • Psychiatry
    • Reproductive Medicine

    Background:

    • Hyperprolactinemia, elevated prolactin levels, can affect various physiological processes.
    • Prolactin's influence on psychological states is not fully understood.
    • Amenorrhea is a common symptom associated with hyperprolactinemia.

    Purpose of the Study:

    • To investigate the psychological effects of hyperprolactinemia.
    • To compare the psychological states of women with hyperprolactinemic amenorrhea to other groups.
    • To examine psychological differences in hyperprolactinemic males.

    Main Methods:

    • Self-rated hostility, depression, and anxiety assessments.
    • Comparison between hyperprolactinemic women, women with amenorrhea only, normal women, and postpartum women.

    Related Experiment Videos

  • Comparison between hyperprolactinemic males and matched control males.

    • Main Results:

    • Women with hyperprolactinemic amenorrhea reported higher hostility, depression, and anxiety than controls.
    • Postpartum women showed less depression and anxiety than hyperprolactinemic amenorrheic women.
    • Hyperprolactinemic males did not exhibit increased hostility or depression compared to controls.

    Conclusions:

    • Elevated prolactin levels are associated with negative psychological states in women.
    • Hyperprolactinemia may contribute to mood disturbances like depression and anxiety.
    • Psychological impacts of hyperprolactinemia appear to differ between sexes.