Effects of prolactin on central dopaminergic neurons

The activities of various dopaminergic neurons in the brain have been estimated biochemically by quantifying the rate of synthesis or turnover of dopamine in brain regions containing the terminals of these neurons. In addition, the activity of tuberoinfundibular dopaminergic neurons have been estimated from the concentration of dopamine in pituitary stalk blood. Manipulations which increase concentrations of prolactin in cerebrospinal fluid or serum (systemic or intracerebroventricular injections of prolactin; injections of dopaminergic antagonists or estrogens; implantation of pituitaries under the renal capsule; prolactin secreting tumors) increase the activity of tuberoinfundibular dopaminergic neurons. The activities of other dopaminergic neuronal systems are not affected by prolactin.