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Updated: Aug 17, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
Published on: April 21, 2014
[Surgery in hypertrophic obstructive cardiomyopathy]
Insights
Surgical treatment for hypertrophic obstructive cardiomyopathy (HOCM) improves symptoms and obstruction relief. However, symptoms can return, and surgery does not cure HOCM, necessitating ongoing management.
Area of Science:
- Cardiology
- Cardiac Surgery
- Medical Research
Context:
- Hypertrophic obstructive cardiomyopathy (HOCM) presents a significant challenge in left ventricular outflow tract obstruction.
- Surgical intervention aims to alleviate this obstruction and improve patient outcomes.
Purpose:
- To evaluate the efficacy and long-term results of surgical treatment for hypertrophic obstructive cardiomyopathy.
- To compare different surgical approaches and their impact on patient symptoms, hemodynamics, and survival.
Summary:
- Sixty-four operations were performed on 63 patients with HOCM, resulting in one perioperative death and symptomatic improvement in most patients.
- Symptomatic improvement correlated with the completeness of subvalvular stenosis relief. Late complications include symptom recurrence, heart failure, and sudden death.
- The 15-year actuarial survival rate is 63%. While surgery improves symptoms and hemodynamics, it does not cure HOCM, and long-term effects of different surgical methods are still under investigation.
Impact:
- Surgical myectomy effectively relieves left ventricular outflow tract obstruction in HOCM patients.
- The study highlights the importance of surgical technique in managing HOCM, with varying complication rates associated with different approaches.
- Findings inform operative indications and underscore the need for continued research into the long-term management of HOCM.
Abstract:
The goal of surgical treatment in hypertrophic obstructive cardiomyopathy is the elimination of the obstruction in the left ventricular outflow tract. 64 operations were performed in 63 patients with HOCM and there was 1 perioperative death. All patients, except 5, were symptomatically improved; the extent of symptomatic improvement was positively related to the completeness of relief of the subvalvular stenosis. During the first 5 years after the operation, 20% of the patients experienced reappearance of symptoms, during later follow-up symptomatic deterioration seemed to occur at an even higher rate. Preoperative left and right heart failure was improved in 3 out of 5 patients; this complication occurred in 4 other patients during the late postoperative follow-up. Congestive heart failure was the cause of late death in 5 patients, 3 died suddenly and 1 each of myocardial infarction or arrhythmia. The 15-years, actuarial survival rate is 63% corresponding to the total yearly mortality of 2.6%. The operation improves symptoms, hemodynamics and some of the complications of HOCM. However, surgery does not cure the disease, and it cannot be decided yet whether or not it slows down the progression of this condition. Transventricular and combined transventricular and transaortic myectomy was more efficient for relieving the subaortic stenosis than the purely transaortic approach. A-V block was more frequent after the transventricular approach, and aortic incompetence occurred more often after transaortic myectomy; these complications did not increase the postoperative mortality. A clear effect of the different surgical methods on the long-term results cannot yet be established. Operative indications are reviewed in the light of the presented experiences.
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