Ethanol tolerance measured electrophysiologically in hippocampal slices and not in neuromuscular junctions from...

The electrophysiologically measured effects of perfused ethanol were examined in neuromuscular junctions and hippocampal slices removed concurrently from naive and ethanol-tolerant rats. At the neuromuscular junction, ethanol augmented the frequency height, and half-width of spontaneous miniature endplate potentials (Mepp). No tolerance was noted to these effects in junctions from ethanol-fed animals. Ethanol depressed the stratum radiatum evoked hippocampal CA1 population spike. Clearcut tolerance to this effect was noted in slices from chronically ethanol-fed animals.