Disseminated pulmonary adiaspiromycosis identified in bioptic material from the lung

A disseminated form of pulmonary adiaspiromycosis was estimated in a 48 year old miner. The origin of a hypersensitivity mainly of an immediate allergic type became evident during an immunological examination and was partly indicated also by the tissue reaction and by elevated level of serum IgE (480 I.U.). Of great interest was the finding of a coagulation necrosis in the bioptic material. An examination of functions disclosed signs of a moderate obstruction which was latent when first observed with normal value of lung diffusion capacity. Its activation during stress was indicated by an increase in the value both of the residual volume and the IGV to the upper border of their limits. No apparent changes occurred in the disease during our two-year-investigation. Neither the total state of the patient nor the x-ray picture reflected the effect of a prolonged treatment with antituberculotics.