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Related Experiment Videos

[Codeine seeking behavior in rats using a weight-pulling method].

T Suzuki, J Uesugi, T Kawai

    Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
    |October 1, 1981
    PubMed
    Summary

    Rats developed a strong preference for codeine, demonstrating significant drug-seeking behavior. A novel weight-pulling method effectively quantified this behavior, offering a new tool for addiction research.

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    Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species.

    The Journal of biological chemistry·1992

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Understanding the development of drug preference and seeking behavior is crucial for addiction research.
    • Quantifying the intensity of drug-seeking behavior can inform treatment strategies.

    Purpose of the Study:

    • To investigate the development of codeine preference and drug-seeking behavior in rats.
    • To evaluate a novel weight-pulling apparatus for measuring the intensity of codeine-seeking behavior.

    Main Methods:

    • Rats were trained using a choice paradigm involving codeine-admixed food versus normal food.
    • A weight-pulling apparatus was employed to assess the effort rats would expend for codeine.
    • Maximum pulling weight was measured, and weight-pulling frequency was observed under increasing loads.

    Main Results:

    • Rats rapidly developed a strong preference for codeine-admixed food, maintained for 14 days.
    • Rats exhibited significant weight-pulling behavior, exerting up to 120 g/100 g body weight for codeine.
    • Increased weight load led to more frequent pulling for codeine, despite decreased eating duration.

    Conclusions:

    • The weight-pulling method effectively detects and quantifies drug-seeking behavior in rats.
    • This apparatus provides a reliable measure of the motivation to obtain codeine.
    • Findings suggest the utility of this method for assessing the degree of substance-seeking behavior.

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