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Related Experiment Videos

The composition and dissolution of phytobezoars.

W D Holloway, S P Lee, G I Nicholson

    Archives of Pathology & Laboratory Medicine
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Phytobezoars form from polymerized tannins in unripe fruit. Cellulase enzyme effectively breaks down these tannin-fiber complexes, offering a treatment for gastric phytobezoars.

    Area of Science:

    • Plant biochemistry
    • Gastroenterology
    • Material science

    Background:

    • Phytobezoars are indigestible masses found in the gastrointestinal tract.
    • Their formation is often linked to the consumption of plant matter, particularly unripe fruits.
    • Understanding the composition and formation mechanism is crucial for effective treatment.

    Purpose of the Study:

    • To determine the plant fiber composition of phytobezoars.
    • To elucidate the mechanism of phytobezoar formation.
    • To identify potential therapeutic agents for phytobezoar dissolution.

    Main Methods:

    • Analysis of plant fiber content (cellulose, hemicellulose, lignin, tannins) in phytobezoars.
    • Identification of tannin monomers and polymers using biochemical assays.

    Related Experiment Videos

  • In vitro testing of cellulase enzyme activity on phytobezoar complexes.

    • Main Results:

    • Phytobezoars exhibit high concentrations of polymerized tannins, primarily leucoanthocyanins and catechins.
    • Unripe fruits contain abundant tannin monomers that polymerize in the stomach.
    • The resulting tannin-cellulose-hemicellulose-protein complex is susceptible to degradation by cellulase.

    Conclusions:

    • Phytobezoar formation is attributed to the gastric acid-induced polymerization of tannins from unripe fruit.
    • Cellulase enzyme offers a simple and effective method for treating human gastric phytobezoars.
    • This study highlights the role of specific plant compounds in gastrointestinal conditions.