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Updated: Feb 25, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
[Epidural morphine injections for the treatment of pain]
Abstract:
Morphine in epidural application (2-3 mg in 10 cc saline solution 0,9%) gives a long lasting segmental analgesia. In 15 patients after upperabdominal surgery the overall mean dosage of morphine was 8,85 mg within three days. The effect lasted for about 15 hours per application. No other analgetics were needed. All patients were content with this method of postoperative analgesia. There were no side effects or complications.
Insights
Epidural morphine provides long-lasting pain relief after upper abdominal surgery. This method was effective for approximately 15 hours per dose, with high patient satisfaction and no adverse effects.
Area of Science:
- Anesthesiology
- Pain Management
- Surgical Care
Background:
- Postoperative pain management is crucial for patient recovery.
- Epidural analgesia offers targeted pain relief.
- Morphine is a potent opioid analgesic.
Purpose of the Study:
- To evaluate the efficacy and safety of epidural morphine for postoperative analgesia.
- To determine the required dosage and duration of effect.
- To assess patient satisfaction with this pain management technique.
Main Methods:
- Epidural application of morphine (2-3 mg in 10 cc 0.9% saline) was used.
- 15 patients undergoing upper abdominal surgery were included.
- Dosage and duration of analgesia were monitored over three days.
Main Results:
- Mean total morphine dosage was 8.85 mg over three days.
- Analgesia lasted approximately 15 hours per application.
- No additional analgesics were required for any patient.
Conclusions:
- Epidural morphine provides effective and sustained segmental analgesia.
- This method is well-tolerated, with high patient satisfaction.
- No side effects or complications were observed during the study.
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